Preheat your oven to 350°F (175°C).

In a large bowl, combine ground beef, crushed tortilla chips, salsa, shredded cheddar cheese, chopped onion, egg, taco seasoning, garlic powder, salt, and black pepper. Mix thoroughly.

Shape the mixture into a loaf and place it into a greased baking dish.

Bake for 45 to 50 minutes, checking that the internal temperature reaches 160°F (70°C).

Let the meatloaf rest for 10 minutes before slicing.

Slice and serve warm.